Publications

Obexer, R.; Nassir, M.; Moody, E. R.; Baran, P. S.; Lovelock, S. L. “Modern Approaches to Therapeutic Oligonucleotide Manufacturing” Science 2024, 384 (6692), eadl4015. https://doi.org/10.1126/science.adl4015
Hutton, A. E.; Foster, J.; Sanders, J. E. J.; Taylor, C. J.; Hoffmann, S. A.; Cai, Y.; Lovelock, S. L.; Green, A. P. “An Efficient Pyrrolysyl-tRNA Synthetase for Economical Production of MeHis-Containing Enzymes”. Faraday Discuss. 2024, 252, 295–305. https://doi.org/10.1039/D4FD00019F.

E. R. Moody et al. “An enzyme cascade enables production of therapeutic oligonucleotides in a single operation.” Science, 380,1150-1154 (2023). DOI:10.1126/science.add5892
Taylor, CJ, Hardy, FJ, Burke, AJ, Bednar, RM, Mehl, RA, Green, AP, et al. “Engineering mutually orthogonal PylRS/tRNA pairs for dual encoding of functional histidine analogues.” Protein Science. 2023; 32( 5):e4640. https://doi.org/10.1002/pro.4640

Kyle J. D. Van Giesen, Matthew J. Thompson, Qinglong Meng, and Sarah L. Lovelock, “Biocatalytic Synthesis of Antiviral Nucleosides, Cyclic Dinucleotides, and Oligonucleotide Therapies”, JACS Au 2022, DOI: 10.1021/jacsau.2c00481

S. L. Lovelock, R. Crawshaw, S. Basler, C. Levy, D. Baker, D. Hilvert, A. P. Green, “The Road to Fully Programmable Protein Catalysis” Nature 2022 606, 49-58
A. J. Burke, W. R. Birmingham, Y. Zhuo, B. Zucoloto da Costa, R. Crawshaw, T. W. Thorpe, I. Rowles, J. Finnigan, C. Young, S. J. Charnock, S. L. Lovelock*, N. J. Turner*, A. P. Green* “An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir” J. Am. Chem. Soc. 2022 144, 3761-3765.
R. Crawshaw, A. E. Crossley, L. Johannissen, A. J. Burke, S. Hay, C. Levy, D. Baker, S. L. Lovelock*, A. P. Green*, “Engineering an Efficient and Enantioselective Enzyme for the Morita-Baylis-Hillman Reaction” Nature Chem. 2022, 14, 313-320

E. L. Bell, W. Finnigan, S. P. France, A. P. Green, M. A. Hayes, L. J. Hepworth, S. L. Lovelock, H. Niikura, S. Osuna, E. Romero, K. S. Ryan, N. J. Turner, S. L. Flitsch, “Biocatalysis” Nature Reviews Methods Primer 2021, 1, 46

M. Ortmayer, K. Fisher, J. Basran, E. M. Wolde-Michael, D. J. Heyes, C. Levy, S. L. Lovelock, E. L. Raven, S. Hay, S. E. J. Rigby, A. P Green, “Rewiring the ‘push-pull’ catalytic machinery of a haem enzyme using an expanded genetic code” ACS Catalysis 2020, 10, 2735

A. Burke†, S. L. Lovelock†, A. Frese, R. Crawshaw, M. Ortmayer, M. Dunstan, C. Levy, A. P. Green, ‘’Design and evolution of an enzyme with a non-canonical organocatalytic mechanism’’ Nature 2019, 570, 219
J. F. Hyslop, S. L. Lovelock, A. J. B. Watson, P. W. Sutton, G.-D. Roiban, “N-Alkyl--amino acids in nature and their biocatalytic preparation” J. Biotechnol. 2019, 293, 56

H. K. Philpott, P. J. Thomas, D. Tew, D. E. Fuerst, S. L. Lovelock*, “A versatile biosynthetic approach to amide bond formation” Green Chem. 2018, 20, 3426
S. L. Lovelock, “Whole cell biosynthesis of amides by Escherichia coli expressing a variety of acyl-CoA synthetases and N-acyltransferase” Patent number WO2018029097A1, 2018
J. F. Hyslop, S. L. Lovelock, P. W. Sutton, K. K. Brown, A. J. B. Watson, G.-D. Roiban, “Biocatalytic synthesis of chiral N-functionalized amino acids” Angew. Chem. Int. Ed. 2018, 57, 13821
M. Petchey, A. Cuetos, B. Rowlinson, S. Dannevald, A. Frese, P. W. Sutton, S. L. Lovelock, R. C. Lloyd, I. J. S. Fairlamb, G. Grogan, “Aryl acid specificity of the amide bond synthetase McbA suggests broad potential for the biocatalytic synthesis of amides” Angew. Chem. Int. Ed. 2018, 57, 11584
A. Crameri, M. L. Hill, S. L. Lovelock, M. Schober, D. G. Tew, P. J. Thomas, “Novel processes for the production of oligonucleotides” Patent number WO20180023122A3, 2018

S. L. Lovelock, N. J. Turner, “Phenylalanine ammonia lyase catalyzed asymmetric hydroamination for the synthesis of L-amino acids” Practical methods for biocatalysis and biotransformations, vol 3, Wiley, 2016
F. Parmeggiani, S. L. Lovelock, N. J. Weise, S. T. Ahmed, N. J. Turner, “Synthesis of D- and L-phenylalanine derivatives by phenylalanine ammonia lyases: A multienzymatic cascade process” Angew. Chem. Int. Ed. 2015, 54, 4608
S. L. Lovelock, N. J. Turner, “Bacterial Anabaena variabilis phenylalanine ammonia lyase: a biocatalyst with broad substrate specificity” Bioorg. Med. Chem. 2014, 20, 5555
S. L. Lovelock, R. C. Lloyd, N. J. Turner, “Phenylalanine Ammonia Lyase Catalyzed Synthesis of Amino Acids by an MIO-Cofactor Independent Pathway” Angew. Chem. Int. Ed. 2014, 53, 4652
M. E. Webb, B. A. Yorke, T. Kershaw, S. Lovelock, C. M. C. Lobley, M. L. Kilkenny, A. G. Smith, T. L. Blundell, A. R. Pearson, C. Abell, “Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase” Acta Cryst. 2014, D70, 1166